A seguire sono segnalate una selezione delle pubblicazioni scientifiche dei ricercatori del Centro di Ricerca dal momento di costituzione del centro stesso (2002).

Stem cells from placental amniotic membrane slow lung scarring in pulmonary fibrosis


Stefani FR, Parolini O, Silini AR.
Mesenchymal Stromal Cells: From Therapeutic Option to Therapeutic Target.
Cancers (Basel). 2023 Mar 21;15(6):1873. doi: 10.3390/cancers15061873.

Basile M, Centurione L, Passaretta F, Stati G, Soritau O, Susman S, Gindraux F, Silini A, Parolini O, Di Pietro R.
Mapping of the Human Amniotic Membrane: In Situ Detection of Microvesicles Secreted by Amniotic Epithelial Cells.
Cell Transplant. 2023 Jan-Dec;32:9636897231166209. doi: 10.1177/09636897231166209.

Pozzobon M, D'Agostino S, Roubelakis MG, Cargnoni A, Gramignoli R, Wolbank S, Gindraux F, Bollini S, Kerdjoudj H, Fenelon M, Di Pietro R, Basile M, Borutinskaitė V, Piva R, Schoeberlein A, Eissner G, Giebel B, Ponsaerts P. General consensus on multimodal functions and validation analysis of perinatal derivatives for regenerative medicine applications. Front Bioeng Biotechnol. 2022 Oct 3;10:961987. doi: 10.3389/fbioe.2022.961987.

Silini AR, Parolini O, Ponsaerts P. 
Editorial: Perinatal derivatives and the road to clinical translation, Volume II. 
Front Bioeng Biotechnol. 2022 Dec 21;10:1122728. doi: 10.3389/fbioe.2022.1122728.

Silini AR, Ramuta TŽ, Pires AS, Banerjee A, Dubus M, Gindraux F, Kerdjoudj H, Maciulatis J, Weidinger A, Wolbank S, Eissner G, Giebel B, Pozzobon M, Parolini O, Kreft ME.
Methods and criteria for validating the multimodal functions of perinatal derivatives when used in oncological and antimicrobial applications.
Front Bioeng Biotechnol. 2022 Oct 13;10:958669. doi: 10.3389/fbioe.2022.958669. eCollection 2022.

Papait A, Ragni E, Cargnoni A, Vertua E, Romele P, Masserdotti A, Perucca Orfei C, Signoroni PB, Magatti M, Silini AR, De Girolamo L, Parolini O.
Comparison of EV-free fraction, EVs, and total secretome of amniotic mesenchymal stromal cells for their immunomodulatory potential: a translational perspective.
Front Immunol. 2022 Aug 16;13:960909. doi: 10.3389/fimmu.2022.960909. eCollection 2022.
Flores AI, Pipino C, Jerman UD, Liarte S, Gindraux F, Kreft ME, Nicolas FJ, Pandolfi A, Tratnjek L, Giebel B, Pozzobon M, Silini AR, Parolini O, Eissner G, Lang-Olip I.
Perinatal derivatives: How to best characterize their multimodal functions in vitro. Part C: Inflammation, angiogenesis, and wound healing.
Front Bioeng Biotechnol. 2022 Aug 4;10:965006. doi: 10.3389/fbioe.2022.965006. eCollection 2022. Review.
Litta F, Papait A, Lucchetti D, Farigu S, Parello A, Tenore CR, Campennì P, Silini AR, Giustiniani MC, Parolini O, Sgambato A, Ratto C.
The pathogenesis of cryptoglandular anal fistula: new insight into the immunological profile.
Colorectal Dis. 2022 Aug 2. doi: 10.1111/codi.16290. Online ahead of print.
Papait A, Romoli J, Stefani FR, Chiodelli P, Montresor MC, Agoni L, Silini AR, Parolini O.
Fight the Cancer, Hit the CAF!
Cancers (Basel). 2022 Jul 22;14(15):3570. doi: 10.3390/cancers14153570. Review.
Winkler T, Costa ML, Ofir R, Parolini O, Geissler S, Volk HD, Eder C; HIPGEN Author Consortium
HIPGEN: a randomized, multicentre phase III study using intramuscular PLacenta-eXpanded stromal cells therapy for recovery following hip fracture arthroplasty : a study design..
Bone Jt Open. 2022 Apr;3(4):340-347. doi: 10.1302/2633-1462.34.
Ragni E, Parolini O, Silini AR.
Editorial: MSC-Derived Extracellular Vesicles and Secreted Factors as "Cell-Free" Therapeutic Alternatives in Regenerative Medicine.
Front Bioeng Biotechnol. 2022 Jan 26;10:842128. doi: 10.3389/fbioe.2022.842128.
Silini AR, Papait A, Cargnoni A, Vertua E, Romele P, Bonassi Signoroni P, Magatti M, De Munari S, Masserdotti A, Pasotti A, Rota Nodari S, Pagani G, Bignardi M, Parolini O.
CM from intact hAM: an easily obtained product with relevant implications for translation in regenerative medicine.
Stem Cell Res Ther. 2021 Oct 12;12(1):540. doi: 10.1186/s13287-021-02607-z.

Silini AR, Ponsaerts P, Parolini O. 
Editorial: Perinatal Derivatives and the Road to Clinical Translation, Volume I. 
Front Bioeng Biotechnol. 2021 Aug 11;9:741156. doi: 10.3389/fbioe.2021.741156. 


Tiberio F, Parolini O, Lattanzi W.
Ciliary Signalling and Mechanotransduction in the Pathophysiology of Craniosynostosis.
Genes (Basel). 2021 Jul 14;12(7):1073. doi: 10.3390/genes12071073. Review.


Orticelli V, Papait A, Vertua E, Bonassi Signoroni P, Romele P, Di Pietro L, Magatti M, Teofili L, Silini AR, Parolini O.
Human amniotic mesenchymal stromal cells support the ex vivo expansion of cord blood hematopoietic stem cells.
Stem Cells Transl Med. 2021 Jul 29. doi: 10.1002/sctm.21-0130. Online ahead of print.


Sandonà M, Di Pietro L, Esposito F, Ventura A, Silini AR, Parolini O, Saccone V.
Mesenchymal Stromal Cells and Their Secretome: New Therapeutic Perspectives for Skeletal Muscle Regeneration.
Front Bioeng Biotechnol. 2021 May 13;9:652970. doi: 10.3389/fbioe.2021.652970. eCollection 2021. Review.


Magatti M, Masserdotti A, Cargnoni A, Papait A, Stefani FR, Silini AR, Parolini O.
The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?
Int J Mol Sci. 2021 Mar 26;22(7):3405. doi: 10.3390/ijms22073405. Review.


Ragni E, Papait A, Perucca Orfei C, Silini AR, Colombini A, Viganò M, Libonati F, Parolini O, de Girolamo L.
Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues.
Stem Cells Transl Med. 2021 Mar 3. doi: 10.1002/sctm.20-0390. 


Cargnoni A, Papait A, Masserdotti A, Pasotti A, Stefani FR, Silini AR, Parolini O.
Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy.
Front Bioeng Biotechnol. 2021 Feb 5;9:637737. doi: 10.3389/fbioe.2021.637737. Review.


Papait A, Cargnoni A, Sheleg M, Silini AR, Kunis G, Ofir R, Parolini O.
Perinatal Cells: A Promising COVID-19 Therapy?
Front Bioeng Biotechnol. 2021 Jan 14;8:619980. doi: 10.3389/fbioe.2020.619980. Review.


Ramuta TŽ, Jerman UD, Tratnjek L, Janev A, Magatti M, Vertua E, Bonassi Signoroni P, Silini AR, Parolini O and Kreft ME 
The Cells and Extracellular Matrix of Human Amniotic Membrane Hinder the Growth and Invasive Potential of Bladder Urothelial Cancer Cells. 
Front. Bioeng. Biotechnol. 2020. 8:554530. doi: 10.3389/fbioe.2020.554530


Silini AR, Di Pietro R, Lang-Olip I, Alviano F, Banerjee A, Basile M, Borutinskaite V, Eissner G, Gellhaus A, Giebel B, Huang YC, Janev A, Kreft ME, Kupper N, Abadía-Molina AC, Olivares EG, Pandolfi A, Papait A, Pozzobon M, Ruiz-Ruiz C, Soritau O, Susman S, Szukiewicz D, Weidinger A, Wolbank S, Huppertz B, Parolini O.
Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature.
Front Bioeng Biotechnol. 2020 Dec 17;8:610544. doi: 10.3389/fbioe.2020.610544. Review.


Tschon M, Brogini S, Parrilli A, Bertoldi S, Silini A, Parolini O, Faré S, Martini L, Veronesi F, Fini M, Giavaresi G.
Assessment of the in vivo biofunctionality of a biomimetic hybrid scaffold for osteochondral tissue regeneration.
Biotechnol Bioeng. 2020 Sep 30. doi: 10.1002/bit.27584. Online ahead of print.

Papait A, Stefani FR, Cargnoni A, Magatti M, Parolini O, Silini AR.
The Multifaceted Roles of MSCs in the Tumor Microenvironment: Interactions With Immune Cells and Exploitation for Therapy.
Front Cell Dev Biol. 2020 Jun 19;8:447. doi: 10.3389/fcell.2020.00447. eCollection 2020. Review.

Magatti M, Masserdotti A, Bonassi Signoroni P, Vertua E, Stefani FR, Silini AR, Parolini O.
B Lymphocytes as Targets of the Immunomodulatory Properties of Human Amniotic Mesenchymal Stromal Cells.
Front Immunol. 2020 Jun 9;11:1156. doi: 10.3389/fimmu.2020.01156. eCollection 2020.

Cargnoni A, Romele P, Bonassi Signoroni P, Farigu S, Magatti M, Vertua E, Toschi I, Cesari V, Silini AR, Stefani FR, Parolini O. 
Amniotic MSCs reduce pulmonary fibrosis by hampering lung B-cell recruitment, retention, and maturation.
Stem Cells Transl Med. 2020 Sep;9(9):1023-1035. doi: 10.1002/sctm.20-0068.

Ragni E, Perucca Orfei C, Silini AR, Colombini A, Viganò M, Parolini O, de Girolamo L.
miRNA Reference Genes in Extracellular Vesicles Released from Amniotic Membrane-Derived Mesenchymal Stromal Cells.
Pharmaceutics. 2020 Apr 11;12(4):347. doi: 10.3390/pharmaceutics12040347.

Lange-Consiglio A, Romele P, Magatti M, Silini A, Idda A, Martino NA, Cremonesi F, Parolini O.
Priming with inflammatory cytokines is not a prerequisite to increase immune-suppressive effects and responsiveness of equine amniotic mesenchymal stromal cells.
Stem Cell Res Ther. 2020 Mar 4;11(1):99. doi: 10.1186/s13287-020-01611-z.

Papait A, Vertua E, Magatti M, Ceccariglia S, De Munari S, Silini AR, Sheleg M, Ofir R, Parolini O.
Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine.
Cells. 2020 Jan 6; 9(1). pii: E127. doi: 10.3390/cells9010127.

Ceccariglia S, Cargnoni A, Silini AR, Parolini O.
Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells.
Autophagy. 2020 Jan;16(1):28-37. doi: 10.1080/15548627.2019.1630223. Epub 2019 Jun 18.

Huang YZ, Wu CG, Xie HQ, Li ZY, Silini A, Parolini O, Wu Y, Deng L, Huang YC.
Strontium Promotes the Proliferation and Osteogenic Differentiation of Human Placental Decidual Basalis- and Bone Marrow-Derived MSCs in a Dose-Dependent Manner.
Stem Cells Int. 2019 Nov 22;2019:4242178. doi: 10.1155/2019/4242178. eCollection 2019. 

Ceccariglia S, Alvino A, Del Fà A, Parolini O, Michetti F, Gangitano C. 
Autophagy is Activated In Vivo during Trimethyltin-Induced Apoptotic Neurodegeneration: A Study in the Rat Hippocampus.
Int J Mol Sci. 2019 Dec 25;21(1). pii: E175. doi: 10.3390/ijms21010175.


Magatti M, Stefani FR, Papait A, Cargnoni A, Masserdotti A, Silini AR, Parolini O.
Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance.
Cells. 2019 Nov 7;8(11). pii: E1401. doi: 10.3390/cells8111401. Review.

Silini AR, Masserdotti A, Papait A, Parolini O.
Shaping the Future of Perinatal Cells: Lessons From the Past and Interpretations of the Present.
Front Bioeng Biotechnol. 2019 Apr 10;7:75. doi: 10.3389/fbioe.2019.00075. eCollection 2019.

Wu C, Chen L, Huang YZ, Huang YC, Parolini O, Zhong Q, Tian X, Deng L.
Comparison of the proliferation and differentiation potential of human urine-, placenta decidua basalis-, and bone marrow-derived stem cells.
Stem Cells International 2018 Dec 13;2018:7131532. doi: 10.1155/2018/7131532.

Giampà C, Alvino A, Magatti M, Silini AR, Cardinale A, Paldino E, Fusco FR, Parolini O.
Conditioned medium from amniotic cells protects striatal degeneration and ameliorates motor deficits in the R6/2 mouse model of Huntington's disease.

J Cell Mol Med. 2019 Feb;23(2):1581-1592. doi: 10.1111/jcmm.14113. Epub 2018 Dec 25.

Xue SL, Liu K, Parolini O, Wang Y, Deng L, Huang YC.
Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing.
Burns Trauma. 2018 Dec 18;6:34. doi: 10.1186/s41038-018-0136-x. eCollection 2018.

Teofili L, Silini AR, Bianchi M, Valentini CG, Parolini O.
Incorporating placental tissue in cord blood banking for stem cell transplantation.
Expert Rev Hematol. 2018 Aug;11(8):649-661. doi: 10.1080/17474086.2018.1483717. Review.

Bollini S, Silini AR, Banerjee A, Wolbank S, Balbi C, Parolini O.
Cardiac Restoration Stemming From the Placenta Tree: Insights From Fetal and Perinatal Cell Biology.
Front Physiol. 2018 Apr 11;9:385. doi: 10.3389/fphys.2018.00385. eCollection 2018. Review.

Barba M, Di Pietro L, Massimi L, Geloso MC, Frassanito P, Caldarelli M, Michetti F, Della Longa S, Romitti PA, Di Rocco C, Arcovito A, Parolini O, Tamburrini G, Bernardini C, Boyadjiev SA, Lattanzi W.
BBS9 gene in nonsyndromic craniosynostosis: Role of the primary cilium in the aberrant ossification of the suture osteogenic niche.
Bone. 2018 Apr 17;112:58-70. doi: 10.1016/j.bone.2018.04.013.

Magatti M, Vertua E, Cargnoni A, Silini A, Parolini O.
The Immunomodulatory Properties of Amniotic Cells: The Two Sides of the Coin.
Cell Transplant. 2018 Jan;27(1):31-44. doi: 10.1177/0963689717742819.

Silini AR, Spoldi V, De Munari S, Vertua E, Munarin F, Petrini P, Farè S, Parolini O.
Immunological and Differentiation Properties of Amniotic Cells Are Retained After Immobilization in Pectin Gel.
Cell Transplant. 2018 Jan;27(1):70-76. doi: 10.1177/0963689717738786.

Pischiutta F, Sammali E, Parolini O, Carswell HVO, Zanier ER.
Placenta-Derived Cells for Acute Brain Injury.
Cell Transplant. 2018 Jan;27(1):151-167. doi: 10.1177/0963689717732992.

Silini AR, Parolini O.
Placental Cells and Derivatives: Advancing Clinical Translation.
Cell Transplant. 2018 Jan;27(1):1-2. doi: 10.1177/0963689717745332. 

Centurione L, Passaretta F, Centurione MA, Munari S, Vertua E, Silini A, Liberati M, Parolini O, Di Pietro R.
Mapping of the Human Placenta: Experimental Evidence of Amniotic Epithelial Cell Heterogeneity.
Cell Transplant. 2018 Jan;27(1):12-22. doi: 10.1177/0963689717725078.

Maymó JL, Riedel R, Pérez-Pérez, Magatti M, Maskin B, Dueñas JL, Parolini O, Sánchez-Margalet V, Varone CL.
Proliferation and survival of human amniotic epithelial cells during their hepatic differentiation.
PLoS One. 2018 Jan 18;13(1):e0191489. doi: 10.1371/journal.pone.0191489. eCollection 2018.

Cargnoni A, Farigu S, Cotti Piccinelli E, Bonassi Signoroni P, Romele P, Vanosi G, Toschi I, Cesari V, Barros Sant'Anna L, Magatti M, Silini AR, Parolini O.
Effect of human amniotic epithelial cells on pro-fibrogenic resident hepatic cells in a rat model of liver fibrosis.
J Cell Mol Med. 2018 Feb;22(2):1202-1213. doi: 10.1111/jcmm.13396. Epub 2017 Nov 3.

Barboni B, Russo V, Gatta V, Bernabò N, Berardinelli P, Mauro A, Martelli A, Valbonetti L, Muttini A, Di Giacinto O, Turriani M, Silini A, Calabrese G, Abate M, Parolini O, Stuppia L, Mattioli M.
Therapeutic potential of hAECs for early Achilles tendon defect repair through regeneration.
J Tissue Eng Regen Med. 2018 Mar;12(3):e1594-e1608. doi: 10.1002/term.2584. Epub 2017 Nov 17.

Huang YZ, Xie HQ, Silini A, Parolini O, Zhang Y, Deng L, Huang YC.
 Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives.
Stem Cell Rev. 2017 Oct;13(5):575-586. doi: 10.1007/s12015-017-9753-1. Review

Silini AR and Parolini O. Human term placenta as source of stem cells for regenerative medicine.
The EuroBiotech Journal, 2017; 1(s2), pp. 147-150. 

Silini AR, Cancelli S, Signoroni PB, Cargnoni A, Magatti M, Parolini O.
The dichotomy of placenta-derived cells in cancer growth.
Placenta 2017 Nov;59:154-162. doi: 10.1016/j.placenta.2017.05.011. Epub 2017 May 18.

Silini AR, Magatti M, Cargnoni A, Parolini O.
Is immune modulation the mechanism underlying the beneficial effects of amniotic cells and their derivatives in regenerative medicine?
Cell Transplant. 2017 Apr 13;26(4):531-539. doi: 10.3727/096368916X693699. Epub 2016 Nov 3.

Sant'Anna LB, Hage R, Cardoso MA, Arisawa EA, Cruz MM, Parolini O, Cargnoni A, Sant'Anna N.
Anti-fibrotic effects of human amniotic membrane transplantation in established biliary fibrosis induced in rats.
Cell Transplant. 2016 Dec 13;25(12):2245-2257.  doi: 10.3727/096368916X692645.


Pischiutta F, Brunelli L, Romele P, Silini A, Sammali E, Paracchini L, Marchini S, Talamini L, Bigini P, Boncoraglio GB, Pastorelli R, De Simoni MG, Parolini O, Zanier ER.
Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites.
Crit Care Med. 2016 Nov; 44(11): e1118-e1131. doi:10.1097/CCM.0000000000001864

Cahill EF, Sax T, Hartmann I, Haffner S, Holler E, Holler B, Huss R, Günther C, Parolini O, Kolch W, Eissner G.
Mesenchymal stromal cells protect endothelial cells from cytotoxic T lymphocyte induced lysis.
Scand J Immunol. 2016 Sep;84(3):158-64.  doi: 10.1111/sji.12459

Magatti M, Vertua E, De Munari S, Caro M, Caruso M, Silini A, Delgado M and Parolini O.
Human amnion favours tissue repair by inducing the M1-to-M2 switch and enhancing M2 macrophage features.
J Tissue Eng Regen Med. 2017 Oct;11(10):2895-2911. doi: 10.1002/term.2193. Epub 2016 Jul 11.

Huang YC, Parolini O, Deng L, Yu BS.
Should Hypoxia Preconditioning Become the Standardized Procedure for Bone Marrow MSCs Preparation for Clinical Use?
Stem Cells. 2016 Jul;34(7):1992-3. doi: 10.1002/stem.2389

Bigini P, Zanier ER, Saragozza S, Maciotta S, Romele P, Bonassi Signoroni P, Silini A, Pischiutta F, Sammali E, Balducci C, Violatto MB, Talamini L, Garry D, Moscatelli D, Ferrari R, Salmona M, De Simoni MG, Maggi F, Simoni G, Grati FR, Parolini O.
Internalization of nanopolymeric tracers does not alter characteristics of placental cells.
J Cell Mol Med. 2016 Jun;20(6):1036-48. doi: 10.1111/jcmm.12820

Lange Consiglio A, Perrini C, Tasquier R, Deregibus MC, Camussi G, Pascucci L, Marini MG, Corradetti B, Bizzaro D, De Vita B, Romele P, Parolini O, Cremonesi F.
Equine amniotic microvesicles and their anti-inflammatory potential in a tenocyte model in vitro.
Stem Cells Dev. 2016 Apr 15;25(8):610-21. doi: 10.1089/scd.2015.0348

Pianta S, Magatti M, Vertua E, Bonassi Signoroni P, Muradore I, Nuzzo AM, Rolfo A, Silini A, Quaglia F, Todros T, Parolini O.
Amniotic mesenchymal cells from pre-eclamptic placentae maintain immunomodulatory features as healthy controls.
J Cell Mol Med. 2016 Jan 20(1):157-69. doi: 10.1111/jcmm.12715

Farè S, Bertoldi S, Meskinfam M, Spoldi V, Tanzi MC, Parolini O.
Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC).
Conf Proc IEEE Eng Med Biol Soc. 2015:1753-6. doi:10.1109/EMBC.2015.7318717

Silini AR, Cargnoni A, Magatti M, Pianta S, Parolini O.
The long path of human placenta, and its derivatives, in regenerative medicine.
Front Bioeng Biotechnol. 2015 Oct 19;3:162. Review. doi: 10.3389/fbioe.2015.00162

Bonomi A, Silini A, Vertua E, Signoroni PB, Coccè V, Cavicchini L, Sisto F, Alessandri G, Pessina A, Parolini O.
Human amniotic mesenchymal stromal cells (hAMSCs) as potential vehicles for drug delivery in cancer therapy: an in vitro study.
Stem Cell Res Ther. 2015 Aug 28;6(1):155. doi: 10.1186/s13287-015-0140-z

Wu CG, Zhang JC, Xie CQ, Parolini O, Silini A, Huang YZ, Lian B, Zhang M, Huang YC, Deng L.
In vivo tracking of human placenta derived mesenchymal stem cells in nude mice via (14)C-TdR labeling.
BMC Biotechnol. 2015 Jun 13;15:55. doi: 10.1186/s12896-015-0174-4

Torre ML, Lucarelli E, Guidi S, Ferrari M, Alessandri G, De Girolamo L, Pessina A, Ferrero I; Gruppo Italiano Staminali Mesenchimali (GISM).
Collaboratori: Biagi E, Del Bue M, Frigerio S, Lisini D, Marazzi M, Mareschi K, Nava S, Parolini O, Riccobon A, Romagnoli L, Vigano M.
Ex vivo expanded mesenchymal stromal cell minimal quality requirements for clinical application.
Stem Cells Dev. 2015 Mar 15;24(6):677-85. Epub 2015 Feb 5. doi: 10.1089/scd.2014.0299


Burrai GP, Antuofermo E, Farigu S, Cargnoni A, Bonassi P, Pasciu V, Demontis MP, Parolini O, Varoni MV.
Target-antigen Detection and Localization of Human Amniotic-derived Cells after in Utero Transplantation in Rats.
Annals of Clinical & Laboratory Science. 2015;45(3): 270-7. 

Fierabracci A, Lazzari L, Muraca M, Parolini O.
How far are we from the clinical use of placental-derived mesenchymal stem cells?
Expert Opin Biol Ther. 2015 May;15(5):613-7. doi: 10.1517/14712598.2015.1000856

Pianta S, Bonassi Signoroni P, Muradore I, Rodrigues MF, Rossi D, Silini A, Parolini O.
Amniotic Membrane Mesenchymal Cells-Derived Factors Skew T Cell Polarization Toward Treg and Downregulate Th1 and Th17 Cells Subsets.
Stem Cell Reviews and Reports 2015 Jun;11(3):394-407. doi: 10.1007/s12015-014-9558-4

Kmiecik G, Spoldi V, Silini A, Parolini O.
Current View on Osteogenic Differentiation Potential of Mesenchymal Stromal Cells Derived from Placental Tissues.
Stem Cell Reviews and Reports. 2015 Aug; 11(4):570-85. doi: 10.1007/s12015-014-9569-1

König J, Weiss G, Rossi D, Wankhammer K, Reinisch A, Kinzer M, Huppertz B, Pfeiffer D, Parolini O, Lang I.
Placental mesenchymal stromal cells derived from blood vessels or avascular tissues: What is the better choice to support endothelial cell function?
Stem Cells Dev. 2015 Jan 1;24(1):115-31. doi: 10.1089/scd.2014.0115

Magatti M, Caruso M, De Munari S, Vertua E, De D, Manuelpillai U, Parolini O.
Human amniotic membrane-derived mesenchymal and epithelial cells exert different effects on monocyte-derived dendritic cell differentiation and function.
Cell Transplant. 2015;24(9):1733-52. Epub 2014 Aug 19. doi: 10.3727/096368914X684033

Venegas L, Hettich M, Villena J, Aris R, Párraga M, Parolini O, Alaminos M, Campos A, San Martin S.
Comparative Analysis of Human Amniotic Membrane Graft versus Contact Lenses in Symptomatic Bullous Keratopathy.
J Stem Cell Res Ther. 2014; 4: 250. doi:10.4172/2157-7633.1000250

Barboni B, Russo V, Curini V, Martelli A, Berardinelli P, Mauro A, Mattioli M, Marchisio M, Bonassi Signoroni P, Parolini O, Colosimo A.
Gestational stage affects amniotic epithelial cells phenotype, methylation status, immunomodulatory and stemness properties.
Stem Cell Reviews and Reports. 2014 Oct;10(5):725-41. doi: 10.1007/s12015-014-9519-y

Hennerbichler S, Parolini O.
Amnion: a versatile tissue and cell source in tissue repair and regeneration.
Cell Tissue Bank. 2014 Jun;15(2):175. Epub 2014 Apr 27. doi: 10.1007/s10561-014-9441-1

Cargnoni A, Cotti Piccinelli E, Ressel L, Rossi D, Magatti M, Toschi I, Cesari V, Albertini M, Mazzola S, Parolini O. 
Conditioned medium from amniotic membran-derived cells prevents lung fibrosis and preserves blood gas exchanges in bleomycin-injured mice-specificity of the effects and insights into possible mechanisms.
Cytotherapy. 2014 Jan;16(1):17-32. doi: 10.1016/j.jcyt.2013.07.002

Costa R, Bergwerf I, Santermans E, De Vocht N, Praet J, Daans J, Blon DL, Hoornaert C, Reekmans K, Hens N, Goossens H, Berneman Z, Parolini O, Alviano F, Ponsaerts P.
Distinct in vitro properties of embryonic and extra?embryonic fibroblast?like cells are reflected in their in vivo behaviour following grafting in the adult mouse brain.
Cell Transplant. 2015;24(2):223-33. Epub 2013 Dec 30. doi: 10.3727/096368913X676196

Caruso M, Bonassi Signoroni P, Zanini R, Ressel L, Vertua E, Bonelli P, Dattena M, Varoni MV, Wengler G, Parolini O.
Feasibility and potential of in utero foetal membrane-derived cell transplantation.
Cell Tissue Bank. 2014 Jun;15(2):241-9. doi: 10.1007/s10561-013-9402-0

Parolini O, Souza-Moreira L, O'Valle F, Magatti M, Hernandez-Cortes P, Gonzalez-Rey E, Delgado M. 
Therapeutic effect of human amniotic membrane-derived cells in experimental arthritis and other inflammatory disorders.
Arthritis Rheum. 2014 Feb;66(2):327-39. doi: 10.1002/art.38206

Moodley Y, Vaghjiani V, Chan J, Baltic S, Ryan M, Tchongue J, Samuel CS, Murthi P, Parolini O, Manuelpillai U.
Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study.
PLoS One. 2013 Aug 1;8(8):e69299. doi: 10.1371/journal.pone.0069299

Lange Consiglio A, Rossi D, Tassan S, Perego R, Cremonesi F, Parolini O.
Conditioned medium from horse amniotic membrane-derived multipotent progenitor cells: immunomodulatory activity in vitro and first clinical application in tendon and ligament injuries in vivo.
Stem Cells Dev. 2013 Nov 15;22(22):3015-24. doi: 10.1089/scd.2013.0214


De Girolamo L, Lucarelli E, Alessandri G, Avanzini MA, Bernardo ME, Biagi E, Brini AT, D Amico G, Fagioli F, Ferrero I, Locatelli F, Maccario R, Marazzi M, Parolini O, Pessina A, Torre ML, Italian Mesenchymal Stem Cell Group.
Mesenchymal stem/stromal cells: a new "cells as drugs" paradigm. Efficacy and critical aspects in cell therapy.
Curr Pharm Des. 2013;19(13):2459-73. Review. doi: 10.2174/1381612811319130015


Silini A, Parolini O, Huppertz B, Lang I.
Soluble Factors of Amnion-Derived Cells in Treatment of Inflammatory and Fibrotic Pathologies.
Curr Stem Cell Res Ther. 2013 Jan 1;8(1):6-14. Review. 
doi: 10.2174/1574888X11308010003

Huang YC, Parolini O, Deng L.
The Potential Role of Microvesicles in Mesenchymal Stem Cell-Based Therapy.
Stem Cells Dev. 2013 Mar 15;22(6):841-4. doi: 10.1089/scd.2012.0631

Ricci E, Vanosi G, Lindenmair A, Hennerbichler S, Peterbauer-Scherb A, Wolbank S, Cargnoni A, Signoroni PB, Campagnol M, Gabriel C, Redl H, Parolini O.
Anti-fibrotic effects of fresh and cryopreserved human amniotic membrane in a rat liver fibrosis model.
Cell Tissue Bank. 2013 Sep;14(3):475-88. doi: 10.1007/s10561-012-9337-x

Rossi D, Pianta S, Magatti M, Sedlmayr P, Parolini O.
Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity.
PlosOne. 2012; 7(10):e46956. Epub 2012 Oct 10. doi: 10.1371/journal.pone.0046956

Huang Y, Parolini O, La Rocca G, Deng L.
Umbilical Cord versus Bone Marrow derived Mesenchymal Stromal Cells.
Stem Cells Dev. 2012 Oct 10;21(15):2900-3. doi: 10.1089/scd.2012.0216

Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON.
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993.
J Immunol. 2012 Apr 1;188(7):2936-47.

Magatti M, De Munari S, Vertua E, Parolini O.
Amniotic Membrane-Derived Cells Inhibit Proliferation of Cancer Cell Lines by Inducing Cell Cycle Arrest.
J Cell Mol Med. 2012 Sep;16(9):2208-18. doi: 10.1111/j.1582-4934.2012.01531.x

Ressel L, Ricci E, Bonassi P, Parolini O.
Simultaneous histochemical and immunohistochemical staining as a simple tool to identify mast cells within CD117-positive cell populations.
Histopathology. 2012 Mar;60(4):655-7. doi: 10.1111/j.1365-2559.2011.03957.x

Caruso M, Evangelista M, Parolini O.
Human term placental cells: phenotype, properties and new avenues in regenerative medicine. Review.
Int J Mol Cell Med. 2012;1(2):64-74.

Lehner M, Gotz G, Proff J, Schaft N, Dorrie J, Full F, Ensser A, Muller YA, Cerwenka A, Abken H, Parolini O, Ambros PF, Kovar H, Holter W.
Redirecting T Cells to Ewing’s Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection.
PLoS One. 2012;7(2):e31210. Epub 2012 Feb 15. doi: 10.1371/journal.pone.0031210

Ackerman WE 4th, Bulmer JN, Carter AM, Chaillet JR, Chamley L, Chen CP, Chuong EB, Coleman SJ, Collet GP, Croy BA, de Mestre AM, Dickinson H, Ducray J, Enders AC, Fogarty NM, Gauster M, Golos T, Haider S, Heazell AE, Holland OJ, Huppertz B, Husebekk A, John RM, Johnsen GM, Jones CJ, Kalionis B, König J, Lorenzon AR, Moffett A, Moreira de Mello JC, Nuzzo AM, Parham P, Parolini O, Petroff MG, Pidoux G, Ramírez-Pinilla MP, Robinson WP, Rolfo A, Sadovsky Y, Soma H, Southcombe JH, Tillburgs T, Lash GE.
International Federation of Placenta Associations (IFPA) meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells.
Placenta. 2012 Feb;33 Suppl:S15-22. doi:  10.1016/j.placenta.2011.11.022

Cargnoni A, Ressel L, Rossi D, Poli A, Arienti D, Lombardi G, Parolini O.
Conditioned medium from amniotic mesenchymal tissue cells reduces progression of bleomycin-induced lung fibrosis.
Cytotherapy. 2012 Feb;14(2):153-61. doi: 10.3109/14653249.2011.613930

Lange-Consiglio A, Corradetti B, Bizzaro D, Magatti M, Ressel L, Tassan S, Parolini O, Cremonesi F.
Characterization and potential applications of progenitor-like cells isolated from horse amniotic membrane. 
J Tissue Eng Regen Med. 2012 Aug;6(8):622-35. doi: 10.1002/term.465

König JM, Huppertz B, Desoye G, Parolini O, Fröhlich JD, Weiss G, Dohr G, Sedlmayr P, Lang I.
Amnion-derived mesenchymal stromal cells show angiogenic properties but resist differentiation into mature endothelial cells.
Stem Cells Dev. 2012 May 20;21(8):1309-20. doi: 10.1089/scd.2011.0223


Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato PE, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, van Blitterswijk WJ, Sinigaglia F, Nichols KE, Rubio I, Parolini O, Graziani A.
SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.
The Journal of Immunology. 2011 Dec 1;187(11):5941-51. 
doi: 10.4049/jimmunol.1002476


Sant’Anna LB, Sant’Anna N, Parolini O.
Application of computer-assisted image analysis for identifying and quantifying liver fibrosis in an experimental model.
Journal of Computational Interdisciplinary Sciences. 2011; 2(2): 139-148. 
doi: 10.6062/jcis.2011.02.02.0041


Parolini O, Alviano F, Betz AG, Bianchi DW, Götherström C, Manuelpillai U, Mellor AL, Ofir R, Ponsaerts P, Scherjon SA, Weiss ML, Wolbank S, Wood KJ, Borlongan CV.  
Meeting report of the first conference of the International Placenta Stem Cell Society (IPLASS). 
Placenta. 2011 Oct;32 Suppl 4:S285-90. doi: 10.1016/j.placenta.2011.04.017


Parolini O.
From fetal development and beyond: A continued role for placenta in sustaining life? 
Placenta. 2011 Oct;32 Suppl 4:S283-4. doi: 10.1016/j.placenta.2011.04.009


Manuelpillai U, Moodley Y, Borlongan CV, Parolini O.
Amniotic membrane and amniotic cells: Potential therapeutic tools to combat tissue inflammation and fibrosis? 
Placenta. 2011 Oct;32 Suppl 4:S320-5. Review. doi: 10.1016/j.placenta.2011.04.010


Gervasoni A, Sandri MT, Nascimbeni R, Zorzino L, Cassatella MC, Baglioni L, Panigara S, Gervasi M, Di Lorenzo D, Parolini O.
Comparison of three distinct methods for the detection of circulating tumor cells in colorectal cancer patients. 
Oncology Report. 2011 Jun;25(6):1669-73. Epub 2011 Mar 23. doi: 10.3892/or.2011.1231


Parolini O.
In Utero Hematopoietic Stem-Cell Transplantation-A Match for Mom. 
New England Journal of Medicine. 2011; 364 (12): 1174-1175. 
doi: 10.1056/NEJMcibr1100692


Kaneko Y, Hayashi T, Yu S, Tajiri N, Bae EC, Solomita MA, Chheda SH, Weinbren NL, Parolini O, Borlongan CV.
Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection.
J Pineal Res. 2011 Apr;50(3):272-80. doi: 10.1111/j.1600-079X.2010.00837.x


Parolini O, Caruso M.
Review: Preclinical studies on placenta-derived cells and amniotic membrane: An update.
Placenta. 2011 Mar;32 Suppl 2:S186-95. Review. doi: 10.1016/j.placenta.2010.12.016


Sant'Anna LB, Cargnoni A, Ressel L, Vanosi G, Parolini O.
Amniotic Membrane application reduces liver fibrosis in a Bile Duct Ligation rat model.
Cell Transplantation. 2011;20(3):441-53. doi: 10.3727/096368910X522252


Bertoldi S, Farè S, Denegri M, Rossi D, Haugen H.J, Parolini O, Tanzi M.C.
Ability of polyurethane foams to support placenta-derived cell adhesion and osteogenic differentiation: preliminary results.        
J Mater Sci Mater Med. 2010 Mar; 21(3):1005-11. doi: 10.1016/j.placenta.2011.07.071


Parolini O, Alviano F, Bergwerf I, Boraschi D, De Bari C, De Waele P, Dominici M, Evangelista M, Falk W, Hennerbichler S, Hess DA, Lanzoni G, Liu B, Marongiu F, Mc Guckin C, Mohr S, Nolli ML, Ofir R, Ponsaerts P, Romagnoli L, Solomon A, Soncini M, Strom S, Surbek D, Venkatachalam S, Wolbank S, Zeisberger S, Zeitlin A, Zisch A, Borlongan CV.
Toward cell therapy using placenta-derived cells: Disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table.
Stem Cells Development. 2010 Feb;19(2):143-54. Review. doi: 10.1089/scd.2009.0404


Borlongan CV, Parolini O.
International Placenta Stem Cell Society: Planting the Seed for Placenta Stem Cell Research.
Cell Transplantation. 2010; 19(5):507-8. doi: 10.3727/096368909X480044


Cargnoni A, Di Marcello M, Campagnol M, Nassuato C, Albertini A, Parolini O.
Amniotic membrane patching promotes ischemic rat heart repair.
Cell Transplantation. 2009;18(10):1147-59. doi: 10.3727/096368909X12483162196764


Magatti M, De Munari S, Vertua E, Nassuato C, Albertini A, Wengler GS, Parolini O.
Amniotic mesenchymal tissue cells inhibit dendritic cell differentiation of peripheral blood and amnion resident monocytes.

Cell Transplantation. 2009; 18 (8): 899-914. doi: 10.3727/096368909X471314 


Cargnoni A, Gibelli L, Bonassi Signoroni P, Nassuato C, Arienti D, Lombardi G, Albertini A, Wengler GS, Parolini O.
Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis.

Cell Transplantation. 2009;18(4):405-22. doi: 10.3727/096368909788809857


Yu SJ, Soncini M, Kaneko Y, Hess D, Parolini O, Borlongan C.
Amnion: a potent graft source for cell therapy in stroke.
Cell Transplantation. 2009;18(2): 111-118, Review. doi: 10.3727/096368909788341243


Parolini O, Soncini M, Evangelista M, Schmidt D.
 Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative   medicine?

Regenerative Medicine. 2009;4(2): 275-291. doi: 10.2217/17460751.4.2.275


Evangelista M, Soncini M, Parolini O.
Placenta-derived stem cells: new hope for cell therapy?

Cytotechnology. 2008;58(1): 33-42. doi: 10.1007/s10616-008-9162-z


Gervasoni A, Monasterio Muñoz RM, Wengler GS, Rizzi A, Zaniboni A, Parolini O.
Molecular Signature Detection of Circulating Tumor Cells in Cancer Patients using a Panel of Selected Genes.

Cancer Letters. 2008;263(2): 267-279. doi: 10.1016/j.canlet.2008.01.003


Parolini O, Alviano F, Bagnara GP, Bilic G, Bühring HJ, Evangelista M, Hennerbichler S, Liu B, Magatti M, Mao N, Miki T, Marongiu F, Nakajima H, Nikaido T, Portmann-Lanz CB, Sankar V, Soncini M, Stadler G, Surbek D, Takahashi TA, Redl H, Sakuragawa N, Wolbank S, Zeisberger S, Zisch A, Strom S.C.
Concise Review: Isolation and Characterization of Cells from Human Term Placenta:
Outcome of the First International Workshop on Placenta Derived Stem Cells

Stem Cells. 2008;26(2): 300-311. doi: 10.1634/stemcells.2007-0594


Magatti M, De Munari S, Vertua E, Gibelli L, Wengler GS, Parolini O.
Human amnion mesenchyme harbors cells with allogeneic T cell suppression and stimulation capabilities.
Stem Cells. 2008;26(1):182-192. doi: 10.1634/stemcells.2007-0491


Baldanzi G, Cutrupi S, Chianale F, Gnocchi V, Rainero E, Porporato P, Filigheddu N, van Blitterswijk WJ, Parolini O, Bussolino F, Sinigaglia F, Graziani A.
Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility.
Oncogene. 2008;27 (7): 942-956. doi:10.1038/sj.onc.1210717


Chianale F, Cutrupi S, Rainero E, Baldanzi G, Porporato PE, Traini S, Filigheddu N, Gnocchi VF, Santoro MM, Parolini O, van Blitterswijk WJ, Sinigaglia F, Graziani A.
Diacylglycerol Kinase-{alpha} Mediates HGF-induced Epithelial Cell Scatter by Regulating Rac Activation and Membrane Ruffling.
Mol Biol Cell. 2007;18(12): 4859-4871. doi: 10.1091/mbc.E07-02-0177


Soncini M, Vertua E, Gibelli L, Zorzi F, Denegri M, Albertini A, Wengler GS, Parolini O.
Isolation and Characterization of Mesenchymal Cells from  Human Fetal Membranes.

Journal of Tissue Engineering and Regenerative Medicine. 2007;1(4): 296-305. doi: 10.1002/term.40


Dobbs AK, Yang T, Farmer D, Kager L, Parolini O, Conley M.E.
Cutting Edge: A Hypomorphic Mutation in Ig (CD79b) in a Patient with Immunodeficiency and Leaky Defect in B Cell Development.

J Immunol. 2007;179: 2055-2059. doi: 10.4049/jimmunol.179.4.2055


Lehner M, Bailo M, Stachel D, Roesler W, Parolini O, and Holter W.
Caspase-8 dependent apoptosis induction in malignant myeloid cells by TLR stimulation in the presence of IFN-alpha.

Leukemia Res. 2007;31(12):1729-35. doi:10.1016/j.leukres.2007.05.001


Penza M, Montani C, Romani A, Vignolini P, Pampaloni B, Tanini A, Brandi ML, Alonso-Magdalena P, Nadal A, Ottobrini L, Parolini O, Bignotti E, Calza S, Maggi A, Grigolato PG, Di Lorenzo D.
Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner.

Endocrinology. 2006;147 (12): 5740 – 5751. doi: 10.1210/en.2006-0365


Parolini O. and Soncini M.
Human placenta: a source of progenitor/stem cells?

Journal of Reproductive Medicine and Endocrinology. 2006;3 (2): 117-126. 


Soncini M, Bonassi Signoroni P, Bailo M, Zatti D, Gregori A, Lombardi G, Albertini A, Wengler GS, Parolini O.
Use of highly sensitive mitochondrial probes to detect microchimerism in xenotransplantation models.

Xenotransplantation. 2006;13(1): 80-85. doi: 10.1111/j.1399-3089.2005.00256.x


Wengler GS, Lombardi G, Frusca T, Alberti D, Albertini A, Parolini O.

In utero transplantation of human cord blood cells into rabbits.

Transplantation. 2005;80 (2): 282-3. doi: 10.1097/01.TP.0000163503.12780.5E


Wengler GS, Brocchi E, Lombardi G, Bailo M, Bonassi P, Arienti D, Albertini A, Alberti D, Parolini O.

Conditioning of neonatal pigs using low dose of chemotherapy and murine hybridoma transplantation. Transplantation. 2005;79 (3): 349-52. doi: 10.1097/01.TP.0000150105.74591.8C


Bailo M, Soncini M, Vertua E, Bonassi Signoroni P, Sanzone S, Lombardi G, Arienti D, Calamani F, Zatti D, Paul P, Albertini A, Zorzi F, Cavagnini A, Candotti F, Wengler GS, Parolini O. Engraftment potential of human amnion and chorion cells derived from term placenta. Transplantation. 2004;78 (10): 1439-48.    

doi: 10.1097/01.TP.0000144606.84234.49


Villa R, Bonetti E, Penza ML, Iacobello C, Bulgari G, Bailo M, Parolini O, Apostoli P, Caimi L, Ciana P, Maggi A, Di Lorenzo D.

Target-specific action of organochlorine compounds in reproductive and nonreproductive tissues of estrogen-reporter male mice.

Toxicology and Applied Pharmacology. 2004;201(2):137-48.

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